Study on Transgenic Mice Growing into Craniofacial Anomaly.
نویسندگان
چکیده
منابع مشابه
MRI Phenotyping of Craniofacial Development in Transgenic Mice Embryos
Introduction Craniofacial malformations are involved in three fourths of all congenital birth defects in humans, affecting the development of head, face or neck. TGF-β signaling plays a critical role in regulating palatal fusion. Animal model of inactivated tgfb2 in cranial neural crest (CNC) cells show TGF-β signaling is vital for regulating cell proliferation in the facial region [1]. Microsc...
متن کاملInfluence of growth hormone on the craniofacial complex of transgenic mice.
Growth hormone (GH) secretion affects bone and cartilage physiology. This study investigated the effect of GH on the size of the craniofacial structures and their angular relationship. Three different models of mice with a genetically altered GH axis were used: GH excess (giant), dwarf GH antagonist (dwarf-Ant), and dwarf GH receptor knockout (dwarf-KO) mice. Each model was compared with the co...
متن کاملMothers' reflections on raising a child with a craniofacial anomaly.
OBJECTIVE To conduct a qualitative evaluation of parenting among families with school-aged and young adolescent children with craniofacial anomalies (CFAs). METHODS Interview responses were obtained from nine mothers of children ages 9 to 14 years old with CFAs. Mothers were asked to describe their perceptions of their children, their children's special needs because of CFAs, and their parent...
متن کاملThe effect of tissue expanders on the growing craniofacial skeleton
Background: Tissue expansion can safely be considered one of the major advances in reconstructive plastic surgery. Reported complication rates for tissue expansion have been as low as zero and as high as 48% when expanding the head and neck region in pediatric patients. Our study is to discuss the osseous effects during and after tissue expansion in children. Materials and Methods: Thirty four ...
متن کاملCraniofacial abnormalities induced by ectopic expression of the homeobox gene Hox-1.1 in transgenic mice.
Hox-1.1 is a murine homeobox-containing gene expressed in a time- and cell-specific manner during embryogenesis. We have generated transgenic mice that ectopically express Hox-1.1 from the chicken beta-actin promoter. In these mice Hox-1.1 expression was changed to an almost ubiquitous pattern. Ectopic expression of Hox-1.1 leads to death of the transgenic animals shortly after birth and is ass...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: THE JOURNAL OF THE STOMATOLOGICAL SOCIETY,JAPAN
سال: 1995
ISSN: 1884-5185,0300-9149
DOI: 10.5357/koubyou.62.56